Includes sites related to processes of the Central Dogma of Genetics: transcriotion to mRNA, mRNA splicing, translation to polypeptides, modification of the resulting polypeptides by specific proteolysis and conjugation [MORE] Databases (19) Gene therapy@ (71) Journals (5) Online Bioinformatics@ (6) Polymerase Chain Reaction@ (121) Products & Services (83) Proteomics@ (138) RNA Interference (70) Research Groups (24) Retroviral (5) Ribonucleic acid@ (17) Software (22) 1. Alternative Splicing - Resource for intervention in the key steps in post-translocation regulatory process, with analysis tools and implications in pathologies. Maintained by Exonhit Therapeutics SA, Paris, France. 2. Epigenetic inheritance - Transmission of information from a cell or multicellular organism to its descendants without that information being encoded in the nucleotide sequence of the gene. NodeWorks Encyclopedia article. 3. Expressed Sequence Tag - NodeWorks Encyclopedia article: EST are short sub-sequences of genes, used in mRNA sequencing and in construction of DNA microarrays. 4. Gene Expression - Independent forum for discussion of gene expression. 5. Gene Expression - UCLA Molecular Biology Tutorials on gene expression and gene cloning 6. 3'UTR - NodeWorks Encyclopedia article on the untranslated regions at the ends of mRNA. 7. Alternative Splicing - NodeWorks Encyclopedia article on the process in eukaryotes in which the splicing process of a pre-mRNA can lead to different ripe mRNA molecules and therefore to different proteins. 8. Anatomy of a Comparative Gene Expression Study - Clear explanation of the process of comparing the gene expression in two cell populations or tissue samples by fluorescent microarray technique. 9. Biochemistry of Nucleic Acids - Lecture notes on nucleic acid structure, DNA replication and repair, the genetic code and translation, as well as cancer genes, from Oregon State University, USA 2003. 10. Control of Gene Expression - A collection of diagrams illustrating the fundamentals of molecular biology. 11. Enhancer - NodeWorks Encyclopedia article on enhancers, short pieces of DNA which bind to trans-acting factors to enhance transcription levels of genes. 12. Epigenetic Station - With information, protocols and resources about epigenetics and DNA methylation and much advertising. 13. Epigenetics - NodeWorks Encyclopedia article on processes that lead to inheritance that is not reflected in the sequences of the nuclear DNA. 14. Epigenetics - Article on the site of CellCentric on epigenetics. 15. Eukaryotic Gene Expression Problem Set - Multiple choice questions about post-transcriptional modification of RNA, promoters, and nuclear RNA processing. From: University of Arizona, USA 1997. 16. European Sequencing of Tobacco - A collaboration between Advanced Technologies (Cambridge) Ltd and Tobacco Institute of Bergerac to sequence a large number of tobacco genes. 17. Exon - NodeWorks Encyclopedia article on regions in genes that are expressed in mature mRNA and in proteins. 18. Gene Expression - Article in NodeWorks Encyclopedia. 19. Gene Expression: Transcription - Resource for transcription events during gene formation including schematic diagrams. 20. Gene Regulation - NodeWorks Encyclopedia article on the mechanisms that regulate gene expression. 21. Gene Regulatory Network - NodeWorks Encyclopedia article on the mathematical modelling of gene expression as a network. 22. Genetic Code - NodeWorks Encyclopedia article on the relationship between the nucleic acid base sequence and the corresponding polypeptide amino acid sequence. 23. Genome-Wide Expression - Report on a project to analyze the transcriptional regulatory circuitry of the yeast cell. From the Young Lab at the Whitehead Institute for Biomedical Research. 24. Genomes to Life - The US Department of Energy at Oak Ridge program for research in moleular biology: goals and results. 25. Imprinting - NodeWorks Encyclopedia article on the suppressing of genes by chemical modification, depending on which parent they were received from. 26. Induction of Repair Genes in Yeast - Mercier G., Denis Y., Marc P., Picard L. and Dutreix M.: Transcriptional induction of repair genes during slowing of replication in irradiated Saccharomyces cerevisiae. Mutation Research 487 (dec 2001)157-172: article and supporting background data. 27. Intron - NodeWorks Encyclopedia article on sections of genes that are eliminated by splicing in the formation of mature mRNA and therefore not expressed as proteins. 28. Laboratory of Intelligent Systems NEW! - Project at the Ecole Polytechnique Fédérale de Lausanne (EPFL) creating electronic models of the evolution of gene expression, neural development and similar evolution processes. 29. Mammary Genome Anatomy Project - Forum to integrate various aspects of mammary gland biology, including cellular and developmental aspects, and to promote collaborations and the exchange of ideas, knowledge and resources at NIH, Maryland. 30. Messenger RNA - NodeWorks Encyclopedia article on the RNA that carries information from DNA to protein synthesis. 31. Molecular Genetics Webtext - An online textbook on chromosomes, principles of genetic engineering, basic molecular genetics and experimental methods. 32. Monocistronic - NodeWorks Encyclopedia article: Messenger RNA that codes for one polypeptide string only. 33. Noncoding DNA - NodeWorks Encyclopedia article: sections of DNA that do not contain codes for polypeptide sequences. 34. Operon - NodeWorks Encyclopedia article: group of genes in primitive organisms that are controlled by one operator and one promoter to be activated together. 35. Posttranslational modification - NodeWorks Encyclopedia article: chemical modification of polypeptide chains after synthesis. 36. Pre-mRNA - NodeWorks Encyclopedia article: RNA string syntesized in the cell nucleus before modification (splicing, polyadenylation) and export to the cytoplasm. 37. Prokaryotic Genetics and Gene Expression - Chapter from the Massachusetts Institute of Technology (USA) introductory hypertextbook on molecular biology. 38. Promoter - NodeWorks Encyclopedia article: in genetics a sequence located upstream of a gene that enables its translation. 39. Protein biosynthesis - NodeWorks Encyclopedia article: summary of the process by which the cell converts the DNA sequence proteins. 40. Regulation of Gene Expression - Overview of different aspects of gene expression, including transcription, chromatin modification, and analysis of whole genomes, from Massachusetts Institute of Technology, Cambridge, Mass, USA. 41. Ribosomes - Explanation of how the information encoded in mRNA is translated into a polypeptide. Includes differences between prokaryotes and eukaryotes by John W. Kimball, now retired from Harvard College. 42. RiboWeb Project - Knowledge base that combines data on the structure of the prokaryotic 30S ribosomal subunit that initiates the translation of mRNA into protein, its function and related links and references. 43. RNA Zone - Extensive catalog of links in genomics and proteomics. 44. Role of the Ribosome - Illustrated explanation of the ribosomal protein synthesis by Gwen V. Childs, University of Texas, Galveston, TX. 45. SECIS element - NodeWorks Encyclopedia article: Sequence that directs translation of UGA as selenocysteine insteado of using it as a stop codon. 46. Serial Analysis of Gene Expression - Explanation of Serial Analysis of Gene Expression (SAGE), a method for analysis of gene expression patterns. 47. Shine-Dalgarno sequence - NodeWorks Encyclopedia article: signals the initiation of protein synthesis in bacteria. 48. Signal peptide - NodeWorks Encyclopedia article: short peptide sequences that direct the post-translational transport of proteins after synthesis. 49. Spliceosome - NodeWorks Encyclopedia article: particle composed of DNA and peptide chains that effects mRNA splicing in the cell nucleus of eucaryotic cells. 50. Splicing - NodeWorks Encyclopedia article: in genetics, the process of removing introns from mRNA in the cell nucleus before export to the cytoplasm and use as master for protein synthesis. 51. The Epigenome Network of Excellence - Network of research groups on heritable changes in gene expression without a change in DNA sequence, funded by the European Union. 52. Transcription - NodeWorks Encyclopedia article: in genetics the process by which a DNA sequence is converted to a corresponding RNA sequence. 53. Transcription Factor - Proteins that specifically bind to promotor or enhancer regions on DNA and thereby control the transcription of the downstream gene. 54. Transfer RNA - NodeWorks Encyclopedia article: small RNA molecules that transport amino acids to their positions on the ribosome during polypeptide synthesis. 55. Translation - NodeWorks Encyclopedia article: in genetics, the process by which ribosomes in the cytoplasm transfer the genetic code from a m-RNA sequence to an amino acid sequence in a polypeptide chain.

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